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The concomitant use of insulin or sulfonylureas (SU), known to increase the risk of hypoglycemia, was greater in the older subgroup without obesity (SU 20.5%

Some clinicians recommend gradual dose adjustments to allow appetite regulation to normalize more gradually

It functions as a co-substrate for glutathione peroxidases (GPx) and glutathione S-transferases (GST), and serves as a direct scavenger of reactive oxygen species