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doi: 10.1186/s12864-016-3261-6 76 LogieL.HarthillJ.PatelK.BaconS.HamiltonD
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3.2 GLP-1R agonists in the central nervous system GLP-1R, expressed in endothelial cells, microglia, astrocytes, and neurons, is widely distributed in the hypothalamus, cortex, subventricular zone, and substantia nigra (Hamilton and Holscher, 2009
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Duodenal GLP-1 signaling regulates hepatic glucose production through a PKC--dependent neurocircuitry
Fat loss Studies suggest that most weight lost with retatrutide comes from body fat rather than lean tissue, although preserving muscle mass still depends on: consuming adequate protein undertaking resistance exercise maintaining regular physical activity These remain important parts of any medically supervised weight management programme
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