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Each pathway operates independently, and a single co-prescribed drug may be subject to more than one

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Blocking CXCR4(+) CD4(+) T cells reprograms T(reg)-mediated immunosuppression via modulating the Rho-GTPase/NF-kappaB signaling axis

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Protective roles of hepatic gamma-aminobutyric acid signaling in acute ethanol exposure-induced liver injury

showed in atherosclerosis-prone apolipoprotein E-deficient (ApoE / ) and insulin-resistant mice that lixisenatide can diminish the atherosclerosis burden by reducing the size of atheroma plaques, increasing plaque stability, and reprogramming macrophages to the anti-inflammatory M2 phenotype by enhanced activation of signal transducer and activator of transcription (STAT)3, which is a determinant for M2 macrophage differentiation