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Some GLP-1 medicines have shown cardiovascular benefits and are prioritized for many people with type 2 diabetes who have established heart disease or high cardiovascular risk, according to ADA Standards of Care
CrossRef The shifting burden of gastrointestinal and liver diseases in Southeast Asia and effective control strategies Asian Biomedicine .2025
Perivascular delivery of encapsulated mesenchymal stem cells improves postischemic angiogenesis via paracrine activation of VEGF-A
You may be a candidate if you have: BMI 27 kg/m with obesity-related health problems BMI 30 kg/m Type 2 diabetes with overweight Fatty liver disease PCOS with obesity Sleep apnea High blood pressure Difficulty losing weight despite lifestyle changes A complete medical evaluation is essential before starting treatment
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consideration of dose escalation 6 months : Formal assessment of treatment efficacy according to appropriate criteria: For diabetes (NICE NG28): HbA1c reduction of at least 11 mmol/mol (1.0%) and weight loss of at least 3% For weight management: At least 5% weight loss from baseline on maintenance dose (per SmPC and NICE guidance) Annually thereafter : Ongoing monitoring of metabolic parameters, cardiovascular risk factors, and treatment appropriateness Treatment adjustments may be necessary if: Side effects remain intolerable despite supportive measures Weight loss plateaus before reaching target (may warrant dose increase if not at maximum) Inadequate glycaemic control persists (may require additional diabetes medications) Significant weight loss goals are achieved (maintenance strategies and potential dose reduction) Patients should maintain open communication with their healthcare team, reporting both positive developments and concerns
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