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This side effect appears to be driven by multiple factors, including Mounjaros impact on the brain, reduced peripheral blood flow, decreased thermogenesis from lower food intake, and reduced insulation from weight loss

The first two are approved medicines

As GLP-1 binds to GLP-1 receptors expressed on pancreatic cells, the receptors couple to G-protein subunits and activate adenylate cyclase, which increases the production of cAMP from ATP

Understanding how these medications work helps set realistic expectations about the timeline for seeing results

Studies in animals dont always predict what will occur in humans

A causal link is not established, but it is a reason to keep a clinician involved rather than self-escalating