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NNT CKM was calculated based on the same events as for NNT EXTENDED , in addition to the following clinical and subclinical events that are relevant from a holistic, CKM syndrome perspective: progression to biochemical diabetes (at least one post randomization HbA 1c 6.5%), and a 5-point nephropathy composite

Response may vary across age groups, though evidence for consistent age-related differences in onset of action is limited

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