While individual comfort levels vary, B12 injections are easily tolerated by most patients
Arch Ped 14: 467-71 Ljungblad UW, Astrup H, Mrkrid L, Hager HB, Lindberg M, Eklund EA, Bjrke-Monsen AL, Rootwelt T, Tangeraas T
StatPearls (US source) states, Patients generally receive lifelong intramuscular (IM) injections of vitamin B12 (typically 1000 g per month)
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Since IV infusions often combine B12 with complementary nutrients, the broader formulation can occasionally introduce sensitivities that a standalone B12 shot would not
Whilst true toxicity from too much vitamin B12 is exceptionally rare due to the body's natural excretion mechanisms, elevated B12 levels can occur and may signal underlying health conditions