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163 CYP450 enzymes in the liver regulate the metabolism of many anticancer drugs (e.g., imatinib and erlotinib), and altered activity can lead to reduced efficacy or increased toxicity

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Skin density measurable changes have been documented in clinical trials by this window 13

To investigate the specific role of FOXO4, small interfering RNA (siRNA) was used for FOXO4 knockdown

Garca-Gimnez, J