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The concern is that these same pathways are exploited by cancer cells
Additionally, the interaction between substance abuse and depression may worsen depressive symptoms and its prognosis, leading to a vicious cycle that further complicates metabolic health [48]
Because the resulting synthetic molecule can be fully characterized through structural analysis (unlike complex biologics), regulators can treat it as a conventional generic drug rather than a biosimilar
Note: The studies presented in this table describe direct effects of GLP-1 RAs, on macro- and microvascular coronary arteries
In fact, there are currently physicians prescribing GLP-1s off-label to treat SUD and other forms of addiction (Conley, 2025)
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