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The cleavage is mediated by furin peptidase at the S1/S2 site of the spike protein, and by transmembrane protease serine 2 (TMPRSS2) at the S2 site within the S2 domain, as shown in human airway cells 10 ( Figure 2 )

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Liepinsh E, Kuka J, Vilks K, Svalbe B, Stelfa G, Vilskersts R, et al

This provides the background to the recent recommendations on the management of hyperglycaemia in type 2 diabetes by the EASD and ADA [33]

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