The SELECT trial documented significant CRP reductions that correlated with but were not entirely explained by weight loss
However, musculoskeletal symptoms including arthralgia are listed in some product SmPCs with varying frequencies
Many people notice improvement within two to four weeks, although some experience tiredness for longer if dose escalation continues or if gastrointestinal side effects persist
Retrieved from Tchang, B.G., Aras, M., Kumar, R.B., et al
The most frequently reported symptoms include: Nausea (especially during dose increases) Vomiting Diarrhea Constipation Abdominal discomfort Decreased appetite (an expected effect of the medication) For most patients, side effects stay in the tolerable range and tend to taper off as treatment continues
For example, while a single 5 mg vial might cost $84 ($16.80/mg), a bulk pack of 30 mg or 40 mg can bring the rate down to under $8.00/mg