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Despite significant advances in understanding the molecular pathology of PD, effective early diagnostic biomarkers and mechanistically informed therapeutic targets remain elusive
When the peptide was presented at 2 months in the mice, it appeared to decrease the chromosomal aberrations in all three models, the highest being in the SAMP-1 mice with accelerated cell aging
Singly-housing animals, which prevents inter-animal coprophagy, reduces beta diversity of the microbiome compared to stressful (chronic subordinate colony) co-housing conditions 72
Promotion of synaptic complex assembly by PDS5B In RAD51-mediated DNA strand exchange, the presynaptic filament captures duplex DNA to facilitate homology search in a target dsDNA molecule, with the 3-stranded nucleoprotein intermediate referred to as the synaptic complex 23
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