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In addition, the pleiotropic physiological effects of carnitine (e.g., antioxidant, anti-inflammatory and antiapoptotic effects) are particularly important for the protection against kidney diseases, especially drug-induced nephrotoxicity [259]
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Diagnosis requires full blood count showing macrocytic anaemia, serum B12 measurement below 148 pmol/L, and intrinsic factor antibodies to confirm pernicious anaemia
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Inhibition of the plasma membrane L-type Ca 2+ channels results in reduced intracellular Ca 2+ concentration which reduces the capacity to activate myosin light chain kinase, a key enzyme in the contractile activity of smooth muscle
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