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GLP-1 RAs impact cardiac myocytes in conditions such as myocardial infarction, heart failure preserved ejection fraction (HFpEF), and cardiomyopathy
The strong before and after data is for tesamorelin alone, in HIV patients
Effects on HR of the long-acting QW GLP-1 RAs: exenatide LAR, albiglutide and dulaglutide Exenatide LAR A thorough QT study evaluated the effects of steady-state therapeutic (253 and 399 pg/ml) and supra-therapeutic (627 pg/ml) plasma concentrations of exenatide following continuous intravenous infusion of exenatide LAR to healthy individuals (N = 86
Given the limited efficacy of current anti-fibrotic therapies and the substantial morbidity associated with progressive pulmonary fibrosis, identification of novel pathways capable of modulating fibroblast activation and ECM remodelling remains a major therapeutic priority
10.1053/j.gastro.2019.11.312 22 FanY.WangD.HuY.LiuJ.GaoH.WangY.et al (2011)
Microdosing GLP-1s -- using small amounts to reap the same or similar benefits -- has gained popularity, and some online conversations suggest it could be beneficial for a much broader demographic
