This isn't a contraindicationit's a managed consideration requiring coordinated care
Foa PP, Galansino G, Pozza G
and research grants from Boehringer Ingelheim, Carmot Therapeutics, Dompe, Endogenex, Lilly, Novo Nordisk and Sanofi
Covalent inhibitors represent a different strategy, where the inhibitor forms a permanent bond with the enzyme, leading to irreversible inhibition
Angew Chem Int Ed 47:68076810 Javed A et al (2024) O-GlcNAc modification of HSP27 alters its protein interactions and promotes refolding of proteins through the BAG3/HSP70 co-chaperone
Challenges in the clinical translation of PRLMs and future research directions Challenges in the clinical translation of PRLMs As our understanding of inflammation resolution advances, the therapeutic potential of PRLMs across a wide range of diseases has become increasingly evident