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Neelakantan and colleagues (Biochem Pharmacol, 2017) then took the pharmacological step, reporting that selective, membrane-permeable small-molecule NNMT inhibitors reversed high-fat-diet-induced obesity in mice this is the study most directly relevant to the 5-Amino-1MQ class, because it moves from the target matters to a drug against the target does something in a live animal. And again, it is a mouse study
It is a lab-engineered peptide drug with chemical modifications that make it longer-acting and more drug-like compared to native incretin hormones
BPC-157 supports muscle healing by enhancing angiogenesis and reducing inflammation
But the GLP-1 receptor is expressed far beyond the gut and pancreas
Evidence for systemic accumulation with daily dosing is limited
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