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Given the importance of identifying new therapies for BED and the promising outcomes associated with GLP-1 receptor agonists, this article systematically reviews the effects of these drugs on BED, with a specific focus on their impact on anthropometric variables
This leads to a state of lipotoxicity, which impairs insulin signaling pathways and reduces glucose uptake
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The reduced binding protein affinity also means more free IGF-1 LR3 remains available to interact with target tissues
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