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Thymosin Beta-4 binds G-actin monomers and keeps them unpolymerised, creating the intracellular conditions fibroblasts and endothelial cells need to migrate toward damaged tissue

Why It Works: Delivers copper as a cofactor for lysyl oxidase and lysyl hydroxylase, enzymes needed to cross-link and stabilize new collagen Upregulates COL1A1 and COL1A2 collagen gene transcription along with elastin, decorin, and glycosaminoglycan production while modulating matrix metalloproteinase activity for balanced remodeling Promotes angiogenesis and fibroblast proliferation

Glutathione kinetics in normal man and in patients with liver cirrhosis

Previous work shows that DSIP can inhibit hypoxia-induced reduction of mitochondrial respiratory activity and suggests that DSIPs antioxidant mechanisms could contribute to its neuroprotective effects

Alhasan R, Martins GM, Castro PPde, Saleem RSZ, Zaiter A, Fries I, Kleinclauss A, PerrinSarrado C, Chaimbault P, Jnior ENdaS, Gaucher C, Jacob C (2023) Selenoneine-inspired selenohydantoins with glutathione peroxidase-like activity

Contraindications and Special Populations Some people should be careful or not get B12 injections at all