SASP (Senescence-Associated Secretory Phenotype) signaling begins declining as the source cells are eliminated Weeks 2-6: Tissue microenvironments improve as SASP-driven inflammation decreases
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This inhibition blocks DNA synthesis and cell division, particularly in rapidly dividing cells like cancer cells and activated immune cells
As an example, GSTs protect cellular DNA against oxidative damage that can lead to an increase of DNA mutations or induce DNA damage promoting carcinogenesis 9
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