Outcomes vary: Mild cases may improve with treatment Moderate cases may require long-term management Severe cases can become permanent Some patients develop lifelong GI dysfunction after GLP-1 drug use Early diagnosis significantly improves prognosis
Week 0: Take final dose of Semaglutide (Wegovy/Ozempic) Week 1: Begin Tirzepatide at 2.5mg Week 5+: Follow standard Tirzepatide escalation protocol Note: Start at the lowest Tirzepatide dose regardless of previous Semaglutide dose Even patients on maximum Semaglutide doses should start Tirzepatide at 2.5mg
Following Doctors Orders Always adhere to the instructions given by your healthcare provider
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About TRIUMPH-4 and the TRIUMPH clinical trial program TRIUMPH-4 (NCT05931367) is a Phase 3, 68-week, randomized, double-blind, placebo-controlled study comparing the efficacy and safety of retatrutide with placebo in adults with obesity or overweight and knee osteoarthritis