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Baseline assessment helps distinguish pre-existing hepatic abnormalities from treatment-related changes and allows clinicians to track improvements that often accompany metabolic optimization

A thorough clinical assessment is essential to identify underlying causes, which may include pre-existing diabetic complications, musculoskeletal issues, or unrelated conditions requiring specific management

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4 Preclinical evidence: a foundation of neuroprotection The considerable interest in semaglutide as a neurotherapeutic agent is derived from a robust body of preclinical evidence