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However, their long life-span, penetration through the bloodbrain barrier (BBB) 13 , and high therapeutic doses may allow them to directly act on central nervous system GLP-1Rs 12 , thereby causing CNS-dependent side effects
Even then, surgery and medication were unfairly stigmatized, seen as a crutch or last-ditch resort for people who couldnt lose weight on their own. The meteoric rise in popularity of anti-obesity medications (AOMs) like semaglutide and tirzepatide has reshaped the narrative , with more people embracing the pharmaceutical approach to weight loss
"Unsustainable burden" Blue Cross Blue Shield said in 2024, five GLP-1 drug companies accounted for 20% of their total pharmacy spend which topped $300 million last year
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The banana provides natural sweetness and potassium, which helps with the dizziness some GLP-1 users experience from electrolyte shifts
But when the earth cooled during the middle Miocene period, food for our primate ancestors was scarce
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