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Notably, the Roux-en-Y procedure has a greater impact on MASLD than the other procedures, improving or resolving steatosis in 91% of patients and liver fibrosis in 31%

[10] [11] Whilst semaglutide's primary actions target glucose regulation through enhanced insulin secretion, reduced glucagon, and slowed gastric emptying, changes in autonomic function could theoretically affect thermoregulation and vascular tone, though this remains speculative

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They permanently remove the part of the stomach that produces Ghrelin (the hunger hormone), providing a metabolic reset that lasts

Wang C, Youle RJ

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