However, their effectiveness in colorectal cancer, particularly in microsatellite-stable (MSS) CRCwhich account for approximately 90% of casesremains relatively limited [27,28,29]
Doses often cited range from 200 to 500 mcg (micrograms) administered daily, although some go up to 1000 mcg
These are research-context interests, not validated clinical outcomes
Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired
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7) Cardiovascular Considerations Although robust human data is lacking, theoretical cardiovascular concerns include: Changes in exercise tolerance Mild palpitations Blood pressure variability Because metabolic regulators can indirectly influence vascular tone and energy expenditure, individuals with preexisting cardiovascular conditions should exercise caution