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Understanding the Impact of GLP-1 Medications on Mental Health: Pros and Cons Dr
10.1016/j.orcp.2024.02.004 77
The structure of semaglutide is shown below: in the structure of semaglutide, the dipeptide of the terminal sequence is His-Aib (Aib is an unnatural amino acid) which can not be obtained by direct fermentation expression, so that a recombinant engineering bacterium for constructing a polypeptide fragment (semaglutide precursor) for expressing semaglutide except the dipeptide is generally adopted, the semaglutide precursor is obtained by fermentation and then synthesized with the dipeptide to obtain a complete semaglutide peptide sequence, and the 26 th lysine of the peptide sequence is connected with a C18 fatty diacid side chain through a spacer to obtain a semaglutide raw material
The compound has more safety data than efficacy data, which is unusual for a research peptide
Our study found that patients getting care through Ros platform were able to achieve weight loss outcomes and a safety profile consistent with clinical trials