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In the 6-OHDA rat model of PD, levels of PGC-1 were increased by exendin-4 and dual GLP-1/GIP agonist DA5-CH [131]

S.ChenK.BandyD.MinoshimaS.et al

Pharmacies cannot simply market or dispense them without valid prescriptions, storage control, and proper documentation

Despite the compatibility of MT-II with a nasal spray format and the advantages of nasal delivery of peptides, there are some important factors to consider to ensure consistent dosing and maximal effectiveness: The area within the nasal membrane responsible for absorption is small and can accommodate a relatively limited volume of liquid/aerosol delivered via spray

Alternative weight management strategies during this transition period should be explored