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Essays Biochem

Always because of its anti-platelet properties, it has been suggested that GBEs (including seeds and leaves) should be used with caution during pregnancy, particularly around labor, and during lactation (Dugoua et al., 2006)

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Targeting HSPs in autoimmune diseases HSP90 inhibition and inflammatory control HSP90 inhibitors have shown notable immunomodulatory activity in preclinical autoimmune models, consistent with the role of HSP90 in stabilizing signaling proteins that amplify immune activation

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however there are no human studies to substantiate this risk.[] As with other systemic agents, hypersensitivity and hepato-renal dysfunction are notable contraindications for their use