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doi: 10.1128/mBio.01714-20 94 Shi-KunneX.FainoL.van den BergG

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Exceptions might exist for competitive athletes with specific goals and medical supervision, but general users should view doses above 300 mcg with caution

However, some people have difficulty absorbing vitamin B12 from their diet, including dietary restrictions, certain medical conditions like pernicious anemia, or medications that interfere with B12 absorption

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Any discomfort typically resolves within minutes, and providers can take steps to minimize sensation during the procedure