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When combined with the exclusion of patients with either acute or chronic pancreatitis from prior clinical trials, this observation aligns with the caution raised by the American Diabetes Association to avoid use of GLP-1RAs for patients with any history of acute or chronic pancreatitis 27

Narrow-therapeutic-index drugs Drugs where small changes in plasma concentration produce either toxicity or therapeutic failure are the most clinically significant: Warfarin

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Last Updated: Apr 30, 2025