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In conclusion, metabolic disturbances play a crucial role in the pathogenesis, progression, and clinical manifestations of AP

It is characterized by a well defined, symmetrical erythematous and edematous, non-pruritic malar rash, over the nasal bridge and typically sparing the nasolabial folds (Figure 1A and B)

Most users see 60-80% improvement by week 6-8, with final healing occurring over subsequent weeks