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doi: 10.1016/j.gendis.2019.12.008 189 TrotterEWHaganIM

Notably, while DNA repair mechanisms are essential for maintaining genomic stability, they produce intermediate products such as apurinic/apyrimidinic sites that can exacerbate DNA damage [245], implying that DNA damage can set off a vicious cycle of DNA damage and potentially leading to cell death

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It is called Seven Glaciers

Tirzepatide: Another Relevant Comparison Tirzepatide (Mounjaro/Zepbound), a dual GIP/GLP-1 agonist approved by the FDA, provides another useful reference point

Brazeau, P