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Conversely, in another phase 2b study involving patients with T2DM, tirzepatide showed significantly better efficacy in glucose control and weight loss compared to both placebo and dulaglutide, with an acceptable safety and tolerability profile (111)

93 In the randomized clinical trial STEP-HFpEF, patients who did not have T2D were assigned to either semaglutide 2.4 mg once weekly or placebo and followed for 52 weeks

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Middle Phase (Days 7-21) Pain reduction and visible healing progress typically become noticeable within the 5-10 day range