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J Clin Endocrinol Metab (2020) 105(8):e2695709
Gejl M, Gjedde A, Egefjord L, Moller A, Hansen SB, Vang K, et al
In a recent RCT, ertugliflozin improved left ventricular global longitudinal strain in people with type 2 diabetes mellitus and pre-HF, effects associated with increased ACE2 and angiotensin (17) levels, suggesting a potential underlying mechanisms [91]
Here is the specific chemistry driving it: Tryptophan oxidation: The Trp residue at position 1 of DSIP is particularly vulnerable to oxidative degradation
Wang P, Yu L, Gong J, et al
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