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Such efforts are essential to develop more precise and effective personalized treatment strategies

Additionally, Erastin exhibits varying effects on Nrf2 activity across different cell types

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Infiltrating cells in the CNS interact with pathologically deposited -synuclein molecules, which activate pattern-recognition receptors (TLR2, TLR4) on monocytes and microglia, increasing NF-B activation and inflammasome signaling (NLRP3) [127]