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The STEP 1 extension study found that participants who stopped semaglutide regained approximately two-thirds of their previously lost weight within one year
eating disorders, cystic fibrosis, HIV infection, starvation, cachexia
Proc Natl Acad Sci USA 109:79747981 Rashidi-Nezhad A, Talebi S, Saebnouri H, Akrami SM, Reymond A (2014) The effect of homozygous deletion of the BBOX1 and Fibin genes on carnitine level and acyl carnitine profile
BI 456906: discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy
Finally, while this study cannot definitively differentiate between central nervous system and peripheral effects of GLP-1RAs on alcohol intake, it does provide evidence that there is a role for peripheral mechanisms, which should be examined in future studies
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