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Immunohistochemical analysis displayed that metformin did not reduce MMP13 expression and only partially decreased ADAMTS5 levels, and Collagen II in Nrf2 KO mice were not significantly influenced by metformin treatment (Fig

Regular RTPCR (2530 cycles) was used to validate alternative splicing changes

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For patients with IDH (WT)/TET2 (WT) myeloid leukemia, a high level of BCAT1 is a strong predictor of worse survival outcomes, and the BCAT1 level significantly increases on disease relapse (Raffel et al., 2017)

Provides neuroprotective & cognitive support

Popovich, and Mark A