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Medical conditions that reduce response Several conditions can blunt semaglutide effectiveness regardless of whether it is compounded or brand-name: Hypothyroidism , especially untreated or undertreated, slows metabolism and counteracts weight loss Insulin resistance and type 2 diabetes can require higher doses for the same effect PCOS creates hormonal resistance to weight loss interventions Cushing syndrome and other cortisol disorders override appetite suppression mechanisms Certain medications , including some antidepressants, antipsychotics, corticosteroids, and beta-blockers, promote weight gain through independent pathways If you have any of these conditions, semaglutide may still work but could require higher doses or additional interventions

STEP 10 [42] was the first phase 3 trial designed to assess the efficacy of semaglutide 2.4 mg specifically in individuals with obesity and prediabetes

**Contact healthcare professionals**: Reach out to your local poison control center or emergency services immediately

The FDA also sent out two warning letters

Although the two approaches have generated similar results in terms of the long-term growth rate of overall family premiums, there are greater discrepancies in trends for subgroups like small employers and self-funded firms

Doctors use them along with other findings to make a diagnosis