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Summary: Excessive vitamin B12 intake rarely causes toxicity, but very high levels from supplements or injections may be associated with skin reactions such as acne-like eruptions, though serious adverse effects remain exceptionally uncommon

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Over time this imbalance manifests as dark spots, uneven pigmentation, dullness, and loss of firmness

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Side effect profiles are largely similar between oral and injectable semaglutide, with fewer than 10% of patients discontinuing due to adverse effects