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Patients who suddenly increase exercise intensity or duration without adequate conditioning may experience delayed-onset muscle soreness (DOMS) or joint strain, which can be mistakenly attributed to the medication itself

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Thats not always a bad thing, Auton says

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Cryoprotective effect of L-carnitine on motility, vitality and DNA oxidation of [PMID: 23822772] Laboratory literature summary: Cryoprotective effect of L-carnitine on motility, vitality and DNA oxidation of research subjects spermatozoa

For most clients on GLP-1 drugs, this lands at roughly 70 to 80 percent of their pre-medication training volume with similar or slightly reduced intensity