Evidence from rodent studies indicates that TB500 can impact gene networks controlling cellular migration, extracellular matrix turnover, and inflammatory response regulators, contributing to transcriptional profiles that favor remodeling rather than persistent inflammation (28,29)
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This dual-pathway engagement reflects layered neuroendocrine regulation of energy balance
In PD, pairing novel markers, such as seed amplification assays and extracellular vesicle cargo profiling, with specialized imaging modalities (e.g., neuromelanin-sensitive MRI, susceptibility-weighted imaging for iron deposition) has yielded superior diagnostic accuracy and staging resolution [603, 604]
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Diana Harshbarger, R-Tenn., wrote to RFK Jr