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Fourth, MR requires stringent assumptions, i.e., the genetic variants are associated with the exposure, no confounders of the associations of the genetic variants with the outcomes exist, and the genetic variants are not associated with the outcomes other than via affecting the relevant exposure (no pleiotropy) [17]

It is expected that with the in-depth understanding of the release mechanism of DAMPs, such inhibitors are expected to become new therapeutic strategies

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However, these studies are small and need much more follow up work before any conclusions are drawn from it [50]