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Because GLP-1R agonists primarily act in the brain to suppress appetite, identifying stage-specific neural activity patterns is a key next step
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The SURMOUNT clinical trials enrolled primarily non-diabetic participants and demonstrated that tirzepatide produces 20-22% average body weight loss over 68 weeks, with sustained benefits and generally favorable safety profiles
Her reflexes were absent at the knees and 2+ at the biceps, triceps, finger flexors, and ankles
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