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The study utilized a single-blind, randomized, placebo-controlled, crossover design, combined with functional magnetic resonance imaging (fMRI), to analyze the performance of 54 participants (30 with normal insulin sensitivity and 24 with impaired insulin sensitivity) on sensory associative learning tasks while receiving liraglutide and placebo treatments

Our findings indicate that the loss of dopaminergic neurons would start a vicious cycle of decreased dopamine releaseDRD2 signaling deficiencydecreased GSH synthesisoxidative stressdopaminergic neuron death during the progression of PD and explain the mechanism by which GSH decreases in the brains of PD patients (Supplementary Fig

Anatomical site selection also matters

Trials are based on past studies and what has been learned in the laboratory

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MR and HJ critically edited and revised the manuscript