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Much remains to be clarified experimentally, but the hypothesis offers a biologically plausible and clinically suggestive framework for linking endogenous morphine, dopamine, GLP-1 therapeutics, and mitochondrial regulation in one evolutionary narrative

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AMPK suppresses NF-B expression, which lowers the inflammatory response by upregulating SIRT1 expression (Chen et al., 2016)

Vyvanse and Prozac Prozac is an SSRI antidepressant that contains the active drug fluoxetine

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