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Obesity is a chronic medical condition characterized by dysregulated appetite hormones, altered metabolism, and biological defense of elevated body weight
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Increased GIP signaling induces adipose inflammation via a HIF-1-dependent pathway and impairs insulin sensitivity in mice
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Patients with classic PCOS phenotype show alterations in the follicular fluid intermediate metabolites and the cumulus cells have an increase in oxidative stress, which causes the alteration of processes of follicular growth and oocyte development, causing the reduction in the pregnancy rate [61]
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