semaglutide obesity phase 3 A new era': How could change the treatment landscape Semaglutide as a GLP-1 Agonist:

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Semaglutide activates GLP-1 receptors concentrated in the gut, pancreas, and brain

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Available from [Accessed 23 Dec 2024] Sanyal A et al

The difference is that the retatrutide effect is sustained rather than transient