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An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes
1, 2 The Problem: The bodys own GLP-1 is rapidly inactivated by the DPP-4 enzyme, rendering it ineffective for long-term therapeutic use
It is composed of specialized TJs within retinal capillary endothelial cells and retinal pigment epithelial cells (RPE) that maintain the immune privilege and homeostasis of the retina [6]
Monien B., Bergau N., et al
doi:10.1158/1078-0432.CCR-08-2678
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