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While inhibitor kappa B kinase 2 (IKK2) in joint mesenchymal cells is necessary for cartilage destruction and bone erosion, in its absence synovitis still develops, as a result of local immunogenic synovial fibroblasts necroptosis
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Carnitine is a potent fat burner as it transports fat into the cells to be used for energy
Some patients experience anxiety as a less common but documented side effect, likely related to appetite suppression affecting energy intake and blood sugar patterns