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Integrating GLP-1 Agonists into Clinical Practice Transitioning to GLP-1-based therapies requires strategic planning

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N Engl J Med 2021;384:1719-30.ArticlePubMed 31

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Finally, different weight loss medications raised concerns about suicidality in the past, including phentermine/topiramate, bupropion/naltrexone, and especially rimonabant, an inverse agonist for the cannabinoid receptor CB1, which was worldwide withdrawn for increased risk of suicidality.SGLT2 inhibitors for depression are a relatively new topic

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