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GLP-1 receptors are also found in the hippocampus, a key structure for learning and memory
Its not defiance - its desperation
pmid:33392184 74
Leptin, soluble leptin receptors, free leptin index, and their relationship with insulin resistance and BMI: high normal BMI is the threshold for serum leptin increase in humans
Like other G protein-coupled receptors, the GLP-1R undergoes agonist-mediated endocytosis, but the functional and therapeutic consequences of modulating GLP-1R endocytic trafficking have not been clearly defined
This is why gradual dose titration is used and why some people benefit from staying on a lower dose for longer
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